Yu-Chun Chen
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陳郁君 Yu-Chun Chen TEL：037-382185 E-mail：joycechen@nuu.edu.tw Lab：A2-432 Tissue Engineering Lab Speciality : Tissue engineering, medical polymer materials, medical hydrogels, cell therapy, and regenerative medicine |
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Background |
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School |
Major |
Degree |
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National Taiwan University |
Department of Biomedical Engineering |
Doctorate |
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National Taiwan University |
Department of Biomedical Engineering |
Master's degree |
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National Taiwan University of Science and Technology |
Institute of Polymer Science & Engineering |
Bachelor's degree |
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Journal & Paper |
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1. |
Yung-Hsin Cheng, Shu-Hua Yang, Wen-Yu Su, Yu-Chun Chen, Kai-Chiang Yang, Winston Teng-Kuei Cheng, Shinn-Chih Wu, Feng-Huei Lin*, 2010, “Thermosensitive Chitosan- Gelatin-Glycerol Phosphate Hydrogels as a Cell Carrier for Nucleus Pulposus Regeneration: An In Vitro Study”, Tissue Engineering Part A, 16:695-703 |
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2. |
Wen-Yu Su, Yu-Chun Chen, Feng-Huei Lin*, 2010, “Injectable Oxidized Hyaluronic Acid/Adipic Acid Dihydrazide Hydrogel for Nucleus Pulposus Regeneration”, Acta Biomaterialia, 6:3044–55. |
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3. |
Wen-Yu Su, Ko-Hua Chen, Yu-Chun Chen, Yen-Hsien Lee, Ching-Li Tseng, Feng-Huei Lin*, 2011, “An Injectable Oxidated Hyaluronic Acid/Adipic Acid Dihydrazide Hydrogel as a Vitreous Substitute”, Journal of Biomaterials Science, Polymer edition, 22:1777-97 |
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4. |
Yu-Chun Chen, Wen-Yu Su, Shu-Hua Yang, Amit Gefen, Feng-Huei Lin*, 2012, “In Situ Forming Hydrogels Composed of Oxidized High Molecular Weight Hyaluronic Acid and Gelatin for Nucleus Pulposus Regeneration”, Acta Biomaterialia, 9:5181-93. |
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5. |
Wen-Yu Su, Yu-Chun Chen, Feng-Huei Lin*, “A New Type of Biphasic Calcium Phosphate Cement as a Gentamicin Carrier for Osteomyelitis”, Evidence-Based Complementary and Alternative Medicine, 2013 (Article ID 801374) |
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6. |
Chih-Hung Chang*, Yuan-Ming Hsu, Yu-Chun Chen, Feng-Huei Lin, Subramaniam Sadhasivam, Siow-Tung Loo, Sivasubramanian Savitha, 2014, “Anti-Inflammatory effects of hydrophilic and lipophilic statins with hyaluronic acid against LPS-induced inflammation in porcine articular chondrocytes”, Journal of Orthopaedic Research, 32(4): 557-65 |
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7. |
Karl Wu#, Yu-Chun Chen#, Yuan-Ming Hsu, Chih-Hung Chang*. 2016, March. Enhancing Drug Release from Antibiotic-loaded Bone Cement Using Porogens. Journal of the American Academy of Orthopaedic Surgeons, 24(3): 188–195. (#These authors contributed equally to this work.) |
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8. |
M.H. Hu, K.C. Yang , Y.H. Sun, Y.C. Chen, S.H. Yang*, and F.H. Lin. 2017, Nov. In situ forming oxidised hyaluronic acid/adipic acid dihydrazide hydrogel for prevention of epidural fibrosis after laminectomy. Eurp Cell Mater, 13(34):307-320 |
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9. |
Chia-Chun Chen, Chu-Yun Hsiao, Yao-Horng Wang, Yu-Chun Chen, Chih-Hung Chang*, Hsu-Wei Fang*. 2017, Sep. A comparison of distinct bone marrow-derived cells on cartilage tissue engineering. Journal of the Taiwan Institute of Chemical Engineers, 78:32-38 |
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10. |
Yeong-Jang Chen, Jwo-luen Pao, Chiang Sang Chen, Yu-Chun Chen, Chun-Chien Chang, Fang-Ming Hung, and Chih-Hung Chang*. 2017. Jan. Evaluation of New Biphasic Calcium Phosphate Bone Substitute: Rabbit Femur Defect Model and Preliminary Clinical Results. Journal of Medical and Biological Engineering, 37(1): 85–93. |
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11. |
Yu-Chun Chen, Yuan-Ming Hsu, Kinn Poay Tan, Chih-Hung Chang*. 2018. Oct. Intraarticular injection for rabbit knee Osteoarthritis: Effectiveness among hyaluronic acid, platelet-rich plasma, and mesenchymal stem cells. Journal of the Taiwan Institute of Chemical Engineers, 91:138–145. |
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12. |
Yu-Chun Chen, Yu-Wei Chang, Kinn Poay Tan, Yi-Shan Shen, Yao-Horng Wang, Chih-Hung Chang*. 2018, Nov. Can mesenchymal stem cells and their conditioned medium assist inflammatory chondrocytes recovery? PLOS ONE, 13(11):e0205563. |
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13. |
Yu-Chun Chen, Chih-Hung Chang*. 2020 July. Clinical Application of Mesenchymal Stem Cells for Cartilage Regeneration. Journal Plastic and Aesthetic Research, 7:49. |
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14. |
賴建成、陳郁君、雷涵媮、張至宏*。2020 Nov. 退化性膝關節炎再生醫學治療及醫病共享決策之應用Applications of Shared Decision Making for Regenerative Treatment of Knee Osteoarthritis. Formosan Journal of Medicine, 24:6, 659-664. |
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15. |
Karl Wu, Yu-Chun Chen, Shang M Lin, Chih-Hung Chang*. 2021 May. In vitro and in vivo effectiveness of a novel injectable calcitonin-loaded collagen/ceramic bone substitute. Journal of Biomaterials Applications. 35(10):1355-1365. doi: 10.1177/0885328221989984. Epub 2021 Jan 31. |
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16. |
Yu-Chun Chen, Hwa-Chang Liu, Feng-Huei Lin and Chih-Hung Chang*. 2021 March. Development of Engineered Cartilage Product from Bone Marrow Mesenchymal Stem Cells: An Example in Taiwan. Journal of Musculoskeletal Research VOL. 24, NO. 01 |
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17. |
Hung-Hsuan Chen#, Yu-Chun Chen#, San-Ni Yu, Wan-Ling Lai, Yi-Shan Shen, Pei-Chun Shen, Siao-Han Lin, Chih-Hung Chang*, Shing-Mou Lee*. 2022 Jan. Infrapatellar fat pad–derived mesenchymal stromal cell product for treatment of knee osteoarthritis: a first-in-human study with evaluation of the potency marker. Cytotherapy. 24(1):72-85. doi: 10.1016/j.jcyt.2021.08.006. Epub 2021 Oct 22 |
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18. |
Yu-Chun Chen, Hsiu-Jung Liao, Yuan-Ming Hsu, Yi-Shan Shen, and Chih-Hung Chang*. 2022 Apr. 05. Delivery of Mesenchymal Stem Cell in Dialdehyde Methylcellulose-Succinyl-Chitosan Hydrogel Promotes Chondrogenesis in a Porcine Model. Polymers 2022, 14(7), 1474; https://doi.org/10.3390/polym14071474 |
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19. |
Chen, Hung-Hsuan#; Chen, Yu-Chun#; Yu, San-Ni; Lai, Wan-Ling; Shen, Yi-Shan; Shen, Pei-Chun; Lin, Siao-Han; Chang, Chih-Hung; Lee, Shing-Mou*# contributed equally.2022 Jan. Infrapatellar fat pad-derived mesenchymal stromal cell product for treatment of knee osteoarthritis: a first-in-human study with evaluation of the potency marker. Cytotherapy 2022, 24(1),72-85. |
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20. |
Chen, Chih-Jung; Wu, Chun-Yen; Wu, Chi-Wei; Chang, Ching-Wen; Huang, Tsung-Tao; Shiao, Ming-Hua; Lin, Chu-Kuei; Chen, Yu-Chun; Lin, Yung-Sheng*, “Metal-enhanced fluorescence through conventional Ag-polyethylene glycol nanoparticles for cellular imaging”, RSC ADVANCES, 13(38):26545-26549, 2023 |
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Conference |
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1. |
Yu-Chun Chen, Feng-Huei Lin*, 2007, “In Vitro Biocompatible Evalua-tion of Nucleus Pulposus Cells Cultured in Hyaluronan/Alginate Beads” 4th European Symposium on Biopolymers (ESBP), Oral presentation. |
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2. |
Yu-Chun Chen, Wen-Yu Su, Feng-Huei Lin*, 2009, “Injectable Hy-aluronic Acid / Adipic Acid Dihydrazide for Nucleus Pulposus Regeneration”, Annual Meeting of Formosa Association of Regenerative Medicine Oral presentation |
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3. |
Yu-Chun Chen, Wen-Yu Su, Feng-Huei Lin*, 2010, “In Situ Forming Hyaluronic Acid Hydrogel for Nucleus Pulposus Regeneration : Rheological Properties and Gene Expression”, International Symposium of Materials on Regenerative Medicine (ISOMRM), Oral presentation |
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4. |
Yu-Chun Chen, Wen-Yu Su, Feng-Huei Lin*, “Rheological Characterization of Injectable Hyaluronic Acid Hydrogel for Nucleus Pulposus Regeneration”, NHRI Research Day, Mar., 2010, Zhunan, Taiwan, Poster Presentation (Excellent Poster Award) |
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5. |
Yu-Chun Chen, Wen-Yu Su, Feng-Huei Lin*, 2011, “In Situ Forming Hyaluronic Acid Hydrogel for Nucleus Pulposus Regeneration: Rhe-ological Properties and Gene Expression”, Tissue Engineering International & Regenerative Medicine Society (TERMIS), Oral presentation |
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6. |
Wen-Yu Su, Yu-Chun Chen, Feng-Huei Lin*, “An Injectable Oxidated Hyaluronic Acid/Adipic Acid Dihydrazide Hydrogel as a Vitreous Substitute”, NHRI Research Day, Mar., 2011, Zhunan, Taiwan, Poster presentation |
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7. |
Yu-Chun Chen, Wen-Yu Su, Feng-Huei Lin*, “Injectable Hyaluronic Acid-Gelatin Hydrogel for Nucleus Pulposus Regeneration: Viscoelastic Properties, Cell Behavior, and Gene Expression Analysis”, NHRI Research Day, Mar., 2012, Zhunan, Taiwan, Poster presentation |
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8. |
Yu-Chun Chen, Wen-Yu Su, Feng-Huei Lin*, “In Situ Forming Hyaluronic Acid-based Hydrogel for Nucleus Pulposus Regeneration: An Experimental Study Using an Animal Model”, NHRI Research Day, Mar., 2013, Zhunan, Taiwan, Oral Presentation (Elected Paper Award) |
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9. |
Yu-Chun Chen, Kinn Poay Tan, Chih-Hung Chang*, 2014, “Bone Marrow Mesenchymal Stem Cells Reduced LPS- Induced Inflammatory Response in Chondrocytes”, World Congress on Preventive and Regenerative Medicine (WCPRM), Oral presentation. |
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10. |
Yu-Chun Chen, Yuan-Ming Hsu, Ruo-Yu Chen, Chih-Hung Chang*, 2014, “Acellular Cartilage Matrix for Cartilage Tissue Engineering: Preparation, Characterization, and Biocompatibility Evaluation”, World Congress on Preventive and Regenerative Medicine (WCPRM), Oral presentation. |
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11. |
Yu-Chun Chen, Yuan-Ming Hsu, Kinn Poay Tan, Chih-Hung Chang*, 2015, “Comparison of Platelet-rich Plasma or Hyaluronic Acid with/without Bone Marrow Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis in a Rabbit Model”, Annual Meeting of Formosa Association of Regenerative Medicine, Oral presentation. |
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12. |
Ｙu-Chun Chen, Ruo-Yu Chen, Yuan-Ming Hsu and Chih-Hung Chang*, 2016, “Acellular Cartilage Matrix Combined with Chtosan Cellulose Hydrogel for Cartilage Regeneration: Cell-compatibility and Gene Expression Analysis”, 2016 Tissue Engineering and Regenerative Medicine International Society- Asia Pacific Meeting, Oral presentation. |
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13. |
Yu-Chun Chen, Yi-Shan Shen, Feng- Hui Lin, Chih-Hung Chang*, 2016, “In Situ Forming Thermosensitive Hydrogel Combined with ACM for One-stage Cartilage Defect Treatment”, Annual Symposium on Biomedical Engineering and Technology Engineering and Technology, Poster presentation. |
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14. |
Yu-Chun Chen, Ruo-Yu Chen, Yi-Shan Shen,Yuan-Ming Hsu and Chih-Hung Chang*, 2017, “Acellular Cartilage Matrixc Combined with Chitosan Cellulose Hydrogel for Cartilage Regeneration: Cellcompatibility and Gene Expression Analysis”, International Conference of Development Biology, Stem Cell and Regenerative Medicine, Poster presentation. |
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15. |
Yu-Chun Chen, Wen-Yu Su, Yi-Shan Shen, Feng- Hui Lin and Chih-Hung Chang*, 2018, “Hyaluronic Acid-based Thermosensitive Hydrogel Combined with Acellular Cartilage Matrix for Cartilage Defect Treatment” IUPESM 2018 - World Congress on Medical Physics & Biomedical, Oral presentation |
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16. |
Yu-Chun Chen, Hung-Hsuan Chen, Ni-En Jiang, Yi-Shan Shen, Hsiu-Jung Liao, Shing-Mou Lee, Chih-Hung Chang. 2021. Anti-inflammation effect of infrapatellar fat pad mesenchymal stem cell for osteoarthritis treatment. Tissue Engineering and Regenerative Medicine International Society (TERMIS) World Congress, Maastricht, Netherlands. Online Meeting. |
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17. |
Ching-Wen Chang, Kuo-Teng Hsu, Yu-Chun Chen*. 2022. Development of Quercetin contained Hyaluronic Acid Hydrogel as a Vitreous Substitute. Annual Meeting of Biomaterials and Controlled Releases Society in Taiwan. Hsinchu, Taiwan. Poster presentation. |
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18. |
Yun-Qing Sun, Yan-Ping Song, Yu-Chun Chen*. 2022. Anti-Inflammation Ability Evaluation of Different Cultivation Microenvironment Mesenchymal Stem Cell Derived Exosome. Annual Meeting of Biomaterials and Controlled Releases Society in Taiwan. Hsinchu, Taiwan. Poster presentation |
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19. |
Yu-Ping Chen, Chih-Hung Chang, Feng-Huei Lin, Yu-Chun Chen*. 2022. The Study of Extracellular Vesicles Derived from Micromass Cultivated MSC for Cartilage Matrix Synthesis Promotion. MRS-Taiwan Annual Meeitng, Miaoli, Taiwan. Poster presentation. |
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20. |
Po-Jui Li, Li-Yi Hsieh, Yu-Chun Chen*, Mass Spectrometry and Antioxidant Analysis of Djulis (Chenopodium Formosanum) Water Extract., The Application of Emerging Technologies on Regenerative Medicine/ 2024 Annual Meeting of FARM,台北/臺大醫學院, 2024.03.02~2024.03.02 |
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21. |
Li-Yi Hsieh, Po-Jui Li, Yu-Chun Chen*, Evaluation of Anti-inflammatory Activity of Djulis Extract on IL-1β-stimulated Human Retinal Pigment Epithelial Cells., The Application of Emerging Technologies on Regenerative Medicine / 2024 Annual Meeting of FARM., 台北/臺大醫學院, 2024.03.02~2024.03.02 |
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22. |
Yong-Sheng Chen, Ching-Wen Chang, Yu-Chun Chen*, A Perspective on Quercetin Research in Treating Inflammation in Retinal Pigment Epithelial Cells., 2024 7th NIT-NUU Bilateral Academic Conference (2024年第七屆台日雙邊研討會), 苗栗, 2024.07.14~2024.07.15 |
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Patent |
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1. |
Feng-Huei Lin, Wen-Yu Su, Yu-Chun Chen, Ko-Hua Chen. “Cross-linked oxidized hyaluronic acid for use as a vitreous substitute.” United States Patent US8,197,849 B2. 2012/06~2030/08 |
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2. |
林峯輝、蘇文郁、陳郁君、陳克華，“交聯氧化玻尿酸作為眼球玻璃體之替代物”，中華民國TWI389713，專利期間2013/03~2030/10 |
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3. |
林峰辉、苏文郁、陈克华、陈郁君，“交联氧化透明质酸作为眼球玻璃体之替代物”，中華人民共和國CN 102762647 A，專利期間2014/12~2032/10 |
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4. |
Feng-Huei Lin, Wen-Yu Su, Yu-Chun Chen, Ko-Hua Chen. “Cross-linked oxidized hyaluronic acid for use as a vitreous substitute.” Australian Patent AU2011215775B2. 2012/04~2031/02 |
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5. |
Feng-Huei Lin, Wen-Yu Su, Yu-Chun Chen, Ko-Hua Chen. “Cross-linked oxidized hyaluronic acid for use as a vitreous substitute.” Patent Cooperation Treaty (PCT) WO2011100469A1. 2011/08~2031/02 |
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6. |
Feng-Huei Lin, Wen-Yu Su, Yu-Chun Chen, Ko-Hua Chen. “Cross-linked oxidized hyaluronic acid for use as a vitreous substitute.” Spain Patent ES2535115T3. 2015/05~2031/02 |
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7. |
Feng-Huei Lin, Wen-Yu Su, Yu-Chun Chen, Ko-Hua Chen. “Cross-linked oxidized hyaluronic acid for use as a vitreous substitute.” European Patent EP2534200B1. 2015/04~2031/02 |
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8. |
Feng-Huei Lin, Wen-Yu Su, Yu-Chun Chen, Ko-Hua Chen. “Cross-linked oxidized hyaluronic acid for use as a vitreous substitute.” Canada Patent CA2786911C. 2015/10~2031/02 |
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9. |
Yu-Chun Chen, Wen-Yu Su, Yen-Hsien Lee, Ko-Hua Chen, Feng-Huei Lin. “Gamma-polyglutamic acid-based ocular irrigating solutions” Patent Cooperation Treaty (PCT) WO2011127221A1. 2011/10~2031/04 |
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10. |
Yu-Chun Chen, Wen-Yu Su, Yen-Hsien Lee, Ko-Hua Chen, Feng-Huei Lin. “Gamma-polyglutamic acid-based ocular irrigating solutions” European Patent EP2555780B1. 2016/02~2031/04 |
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11. |
陈郁君、苏文郁、李彦贤、陈克华、林峰辉，“γ-聚麸胺酸类眼科手术冲洗液”，中華人民共和國CN102939092B. 2015/10~2031/04 |
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12. |
Yu-Chun Chen, Wen-Yu Su, Yen-Hsien Lee, Ko-Hua Chen, Feng-Huei Lin. “Gamma-polyglutamic acid-based ocular irrigating solutions” Australian Patent AU2011237671B2. 2014/04~2031/04 |
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13. |
Yu-Chun Chen, Wen-Yu Su, Yen-Hsien Lee, Ko-Hua Chen, Feng-Huei Lin. “Gamma-polyglutamic acid-based ocular irrigating solutions” Canada Patent CA2794563C. 2014/11~2031/04 |
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14. |
林峯輝、陳郁君、蘇文郁、李彥賢、陳克華，“γ-聚麩胺酸類眼科手術沖洗液”，中華民國TWI482639B. 2015/05~2031/04 |
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15. |
Yu-Chun Chen, Wen-Yu Su, Yen-Hsien Lee, Ko-Hua Chen, Feng-Huei Lin. “Gamma-polyglutamic acid-based ocular irrigating solutions” United States Patent US9457000B2. 2016/10~2031/06 |
