中文姓名：林中英

英文姓名：Chung-Yin Lin

聯絡電話：037-382206

E-mail：CYLin7@nuu.edu.tw

負責實驗室：智慧生醫傳輸實驗室

研究專長： 醫用超音波、藥物傳輸、奈米生醫工程、毒物化學

主要學歷

畢/肆業學校

主修學門系所

學位

國立臺灣大學

醫學工程研究所

博士

國立臺北大學

統計學系

碩士

國立陽明交通大學

應用化學研究所

碩士

長庚大學

化學工程學系

學士

期刊與審查論文

1.

Dar-Fu Tai, Sue-Chen Wang, Lisa Chen, Venkatachalam Angamuthu,

Chung-Yin Lin*, 2026, Constructing the active sites of an artificial

hydrolase using mercaptoethanol as a destructive agent, Bulletin of

Chemical Reaction Engineering & Catalysis, 21(2), 362-369.

2.

Adilet Beishenaliev, Yean Leng Loke, Chung-Yin Lin^#, Sook Jing Goh,

Jaya Seema, Yuhan Huang, Xin Yun Lim, Yu-Wen Chen, Bey Fen Leo,

Chia-Yu Chang, Lip Yong Chung, Chia Ching Chang, Yin Yin Teo, Dennis

W. Hwang, Lik Voon Kiew*, 2025, Ultrasmall gold nanoparticles as

“Three-in-one” enzyme-mimicking nanocatalysts for combined

sonodynamic/catalytic therapy in breast cancer. ACS Applied Materials

& Interfaces, 17, 67529-67542.

3.

Te-Hsien Lin, Pei-Hsuan Tseng, I-Cheng Chen, Chung-Yin Lin, Ming-

Chung Lee, Kuo-Hsuan Chang, Guey-Jen Lee-Chen, Chiung-Mei Chen*,

2025, The potential of mulberry (Morus alba L.) leaf extract against

proaggregant Tau-mediated inflammation and mitochondrial

dysfunction, Neurochemistry International, 190, 106042.

4.

Tzu-Chieh Lin, Chung-Yin Lin*, Yi-Ting Hwang, Dar-Fu Tai, 2025, Paper-

Based molecularly imprinted film designs for human serum albumin,

Talanta Open, 11, 100421.

5.

Kuo-Hsuan Chang, Mei-Ling Cheng, Hsiang-Yu Tang, Chung-Yin Lin,

Chiung-Mei Chen*, 2024, Dys-regulation of choline metabolism and

therapeutic potential of citicoline in Huntington's disease, Aging Cell,

23, e14302

6.

Chiung-Mei Chen, Ching-Yun Huang, Chin-Hui Lai, Yu-Chieh Chen,

Yi-Ting Hwang, Chung-Yin Lin*, 2024, Neuroprotection effects of

kynurenic acid-loaded micelles for the Parkinson’s disease models,

Journal of Liposome Research, 34, 593-604.

7.

Yean Leng Loke, Adilet Beishenaliev, Pei-Wen Wang, Chung-Yin Lin^#,

Chia-Yu Chang, Yiing Yee Foo, Farid Nazer Faruqu, Bey Fen Leo, Misni

Misran, Lip Yong Chung, Dar-Bin Sheih, Lik Voon Kiew*, Chia-Ching

Chang*, Yin Yin Teo*, 2023, ROS-generating alginate-coated gold nanorods as biocompatible nanosonosensitisers for effective sonodynamic therapy of cancer, Ultrasonics Sonochemistry, 2023, 106437.

8.

Pei-Ning Yang , Wan-Ling Chen, Jun-Wei Lee, Chih-Hsin Lin, Yi-Ru Chen,

Chung-Yin Lin, Wenwei Lin, Ching-Fa Yao, Yih-Ru Wu, Kuo-Hsuan

Chang, Chiung-Mei Chen, Guey-Jen Lee-Chen*, 2023, Coumarin–

chalcone hybrid LM-021 and indole derivative NC009-1 targeting

inflammation and oxidative stress in Parkinson’s disease cell models.

Aging (Albany NY), 15, 8061-8089.

9.

Ya-Jen Chiu, Chih-Hsin Lin, Chung-Yin Lin, Pei-Ning Yang, Yen-Shi Lo,

Yu-Chieh Chen, Chiung-Mei Chen, Yih-Ru Wu, Ching-Fa Yao, Kuo-Hsuan

Chang, Guey-Jen Lee-Chen*, 2023, Investigating therapeutic effects of

indole derivatives targeting inflammation and oxidative stress in

neurotoxin-induced cell and mouse models of Parkinson’s disease,

International Journal of Molecular Sciences, 24, 2642.

10.

Kiran Reddy Kanubaddi, Ching-Lun Yang, Pei-Yu Huang, Chung-Yin

Lin*, Dar-Fu Tai, Chia-Hung Lee, 2022, Peptide conformational imprints

enhanced the catalytic activity of papain for esterification. Frontiers in

Bioengineering and Biotechnology, 1, 943751.

11.

Cheng-Hsin Wu, Chung-Yin Lin*, Tzu-Chieh Lin, Dar-Fu Tai, 2022, Integration of adenylate kinase 1 with its peptide conformational imprint, International Journal of Molecular Sciences, 23, 6521.

12.

Chung-Yin Lin, Ching-Yun Huang, Chiung-Mei Chen, Hao-Li Liu*, 2022, Focused ultrasound-induced blood-brain barrier opening enhanced a-synuclein expression in mice for modeling Parkinson’s disease, Pharmaceutics, 12, 444.

13.

Wei-Liang Lin, Chung-Yin Lin*, Dar-Fu Tai, 2021, Preparation of a

molecularly imprinted film on quartz crystal microbalance chip for

determination of furanic compounds, Chemosensors, 9, 1-12.

14.

Ya-Jen Chiu, Te-Hsien Lin, Chiung-Mei Chen, Chih-Hsin Lin, Yu-Shan Ten,

Chung-Yin Lin, Ying-Chieh Sun, Hsiu-Mei Hsieh-Li, Guey-Jen Lee-Chen,

Weiwei Lin, Kuo-Hsuan Chang, 2021, Novel synthetic coumarin-

chalcone derivative (E)-3-(3-(4-(dimethylamino)phenly) acryloyl)-4-

hydroxy-2H-chromen-2-one activates CREB-mediated neuroprotection

in Ab and Tau cell models of Alzheimer’s disease, Oxidative Medicine

and Cellular Longevity, 2021, 3058861.

15.

Ni-Ni Chiang, Te-Hsien Lin, Yu-Shan Teng, Ying-Chieh Sun, Kuo-Hsuan

Chang, Chung-Yin Lin, Hsiu-Mei Hsieh-Li, Ming-Tsan Su, Chiung-Mei

Chen, Guey-Jen Lee-Chen*, 2021, Flavones 7,8-DHF, quercetin, and

apigenin against Tau Toxicity via activation of TRKB signaling in DK280

Tau_RD-DsRed SH-SY5Y cells, Frontiers in Aging Neuroscience, 13,

758895.

16.

Chung-Yin Lin*, Subrata Chakraborty, Chia-Wei Wong, Dar-Fu Tai, 2021,

Controversy of peptide cyclization from tripeptide, Molecules, 26, 389.

17.

Chung-Yin Lin, Yu-Chien Lin, Ching-Yun Huang, Shang-Rung Wu,

Chiung-Mei Chen, Hao-Li Liu*, 2020, Ultrasound-responsive

neurotrophic factor-loaded microbubble-liposome complex: preclinical

investigation for Parkinson’s disease treatment, Journal of Controlled

Release, 321, 519-528.

18.

Chien-Yu Chou, Chung-Yin Lin*, Cheng-Hsin Wu, Dar-Fu Tai, 2020,

Sensing HIV protease and its inhibitor using “helical epitope”-

imprinted polymers, Sensors, 20, 3592.

19.

Chih-Hsin Lin, Pei-Cih Wei, Chiung-Mei Chen, Yu-Ting Huang, Jia-Lan

Lin, Yen-Shi Lo, Jia-Li Lin, Chung-Yin Lin, Yih-Ru Wu, Kuo-Hsuan Chang,

Guey-Jen Lee-Chen*, 2020, Lactulose and melibiose attenuate MPTP-

induced Parkinson’s disease in mice by inhibition of oxidative stress,

reduction of neuro-inflammation and up-regulation of autophage.

Frontiers in Aging Neuroscience, 226, 1-11.

20.

Te-Hsien Lin, Ya-Jen Chiu, Chih-Hsin Lin, Chung-Yin Lin, Chih-Ying Chao, Yu-Chieh Chen, Shu-Mei Yang, Wenwei Lin, Hsiu Mei Hsieh-Li, Yih-Ru Wu, Kuo-Hsuan Chang, Guey-Jen Lee-Chen, Chiung-Mei Chen*, 2020, Exploration of multi-target effects of 3-benzoyl-5-hydroxy- chromen-2-one in Alzheimer’s disease cell and mouse models, Aging Cell, 00, e13169.

21.

Chiung-Mei Chen, Chih-Hsin Lin, Yih-Ru Wu, Chien-Yu Yen, Yu-Ting

Huang, Jia-Lan Lin, Chung-Yin Lin, Wan-Ling Chen, Chih-Ying Chao,

Guey-Jen Lee-Chen, Ming-Tsan Su, Kuo-Hsuan Chang*, 2020, Lactulose

and melibiose inhibit a-synuclein aggregation and up-regulate

autophagy to reduce neuronal vulnerability, Cells, 9, 1230.

22.

Chia-Rung Lin, Chung-Yin Lin, Ya-Ting Lin, Chiung-Yin Huang, Kuo-Chen Wei, Jin-Chung Chen, Guey-Jen Lee-Chen, Hao-Li Liu*, 2019, Microbubble-facilitated ultrasound pulsation promotes direct a-synuclein gene delivery, Biochemical and Biophysical Research Communications, 517, 77-83.

23.

Chung-Yin Lin, Chih-Hung Tsai, Li-Ying Feng, Wen-Yen Chai, Chia-Jung Lin, Chiung-Ying Huang, Kuo-Chen Wei, Chih-Kuang Yeh, Chiung-Mei Chen, Hao-Li Liu*, 2019, Focused ultrasound-induced blood brain- barrier opening enhanced vascular permeability for GDNF delivery in Huntington’s disease mouse model, Brain Stimulation, 12, 1143-50.

24.

Chung-Yin Lin, Sheng-Hung Tsai, Dar-Fu Tai, 2019, Detection of

oxytocin, atrial natriuretic peptide, and brain natriuretic peptide using

novel imprinted polymers produced with amphiphilic monomers,

Journal of Peptide Science, 2019, e3150.

25.

Wen-Yen Chai, Po-Chun Chu, Chih-Hung Tsai, Chung-Yin Lin, Hung-Wei

Yang, Hsin-Yi Lai, Hao-Li Liu*, 2018, Image-guided focused-ultrasound

CNS molecular delivery: an implementation via dynamic contrast-

enhanced magnetic-resonance imaging, Scientific Reports, 8, 4151.

26.

Chung-Yin Lin, Rui-Jin Li, Chiung-Yin Huang, Kuo-Chen Wei, Pin-Yuan

Chen*, 2018, Controlled release of liposome-encapsulated

temozolomide for brain tumor treatment by convection-enhanced

delivery, Journal of Drug Targeting, 26, 325-332.

27.

Ching-Hsiang Fan, Chung-Yin Lin, Hao-Li Liu, Chih-Kuang Yeh*, 2017,

Ultrasound targeted CNS gene delivery for Parkinson’s disease

treatment. Journal of Controlled Release, 261, 246-262.

28.

Yung-Liang Wan*, Pei-Kwei Tsay, Patricia Wanping Wu, Yu-Hsiang Juan, Hui-Yu Tsai, Chung-Yin Lin, Chih-Sheng Yeh, Chun-Hua Wang, Chun-Chi Chen, 2017, Impact of filter convolution and displayed field of view on estimation of coronary Agatston scores in low-dose lung computed tomography, International Journal of Cardiology, 236, 451-457.

29.

Pin-Yuan Chen, Chih-Kuang Yeh, Po-Hung Hsu, Chung-Yin Lin, Chiung-

Yin Huang, Kuo-Chen Wei, Hao-Li Liu*, 2017, Drug-carrying

microbubbles as a theranostic tool in convection-enhanced delivery for

brain tumor therapy. Oncotarget, 8, 42359-42371.

30.

Hao-Li Liu*, Po-Hung Hsu, Chung-Yin Lin, Chiun-Wei Huang, Wen-Yen Chai, Po-Chun Chu, Chiung-Yin Huang, Pin-Yuan Chen, Liang-Yo Yang, John S Kuo, Kuo-Chen Wei, 2016, Focused ultrasound enhances CNS delivery of bevacizumab for malignant glioma treatment, Radiology, 281, 99-108.

31.

Chung-Yin Lin*, Han-Yi Hsieh, Chiung-Mei Chen, Shang-Rung Wu, Chih-Hung Tsai, Chiung-Yin Huang, Mu-Yi Hua, Kuo-Chen Wei, Chih-Kuang Yeh, Hao-Li Liu, 2016, Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson’s disease mouse model, Journal of Controlled Release, 235, 72-81.

32.

Ching-Wei Hsu, Cheng-Hao Weng, Dan-Tzu Lin-Tan, Pao-Hsien Chu, Tzung-Hai Yen, Kuan-Hsing Chen, Chung-Yin Lin, Wen-Hung Huang*, 2016, Association of urinary cadmium with mortality in patients at a coronary care unit, PLoS One, 11, e0146173.

33.

Ching-Hsiang Fan, Chien-Yu Ting, Chung-Yin Lin, Hong-Lin Chan, Yuan-Chih Chang, You-Yin Chen, Hao-Li Liu, Chih-Kuang Yeh*, 2016, Noninvasive, targeted, and non-viral ultrasound-mediated gene delivery for Parkinson’s disease treatment, Scientific Reports, 6, 19579.

34.

Po-Chun Chu, Hao-Li Liu, Hsin-Yi Lai, Chung-Yin Lin, Hong-Chieh Tsai, Yu-Cheng Pei*, 2015, Neuromodulation accompanying focused ultrasound-induced blood brain barrier opening, Scientific Reports, 5, 15477.

35.

Chung-Yin Lin, Han-Yi Hsieh, William G. Pitt, Chiung-Yin Huang, I-Chou Tseng, Chih-Kuang Yeh, Kuo-Chen Wei, Hao-Li Liu*, 2015, Focused ultrasound-induced blood-brain barrier opening for non-viral, non-invasive, and targeted gene delivery, Journal of Controlled Release, 8, 1-9.

36.

Chung-Yin Lin*, William G. Pitt, Kuo-Chen Wei, 2014, Development of ultrasound sensitive eLiposomes containing doxorubicin for drug delivery, Journal of Pharmaceutical Research International, 4, 2296 -2311.

37.

Chung-Yin Lin, Marjan Javadi, David M. Belnap, Jeffery R. Barrow ,

William G. Pitt*, 2014, Ultrasound sensitive eLiposomes containing

doxorubicin for drug targeting therapy, Nanomedicine-NBM, 10, 67-76.

38.

Chung-Yin Lin, William G. Pitt, 2013, Acoustic Droplet Vaporization in Biology and Medicine, BioMed Research International, 2013, 1-13.

39.

Chung-Yin Lin, Jia-Rong Li, Hsiao-Ching Tseng, Ming-Fang Wu, Win-Li Lin*, 2012, Enhancement of focused ultrasound with microbubbles on the treatments of anticancer nanodrug in mouse tumors,  Nanomedicine-NBM, 8, 900-907.

40.

Chung-Yin Lin, Hsiao-Ching Tseng, Heng-Ruei Hsu, Ming-Fang Wu, Cheng-Ying Chou, Win-Li Lin*, 2012, Ultrasound sonication with microbubbles disrupts blood vessels and enhances tumor treatments of anticancer nanodrug, International Journal of Nanomedicine, 7,  2143-2152.

41.

Chung-Yin Lin, Tzu-Ming Liu, Chao-Yu Chen, Yen-Lin Huang, Wei-Kai Huang, Chi-Kuang Sun, Fu-Hsiung Chang, Win-Li Lin*, 2010, Quantitative and qualitative investigation into the impact of focused ultrasound with microbubbles on the triggered release of nanoparticles from vasculature in mouse tumors, Journal of Controlled Release, 146, 291-298.

42.

Chung-Yin Lin, Yen-Lin Huang, Jia-Rong Li, Fu-Hsiung Chang, Win-Li Lin*, 2010, Effects of focused ultrasound and microbubbles on the vascular permeability of nanoparticles delivered into mouse tumors, Ultrasound in Medicine and Biology, 36, 1490-1496.

43.

Ja-Liang Lin*, Dan-Tzu Lin-Tan, Pao-Hsien Chu, Yung-Chang Chen, Yen-Lin Huang, Tai-Chin Ho, Chung-Yin Lin, 2009, Cadmium excretion predicting hospital mortality and illness, Critical Care Medicine, 37, 957-962.

44.

Chung-Yin Lin, Wei-Bor Tsai*, 2006, Biomaterials application and development on blood substitutes, Chemistry (The Chinese Chem. Soc.), 64, 97-104.

45.

Dar-Fu Tai*, Chung-Yin Lin, Tzong-Zeng Wu, Jyh-Hsiung Huang, Pei-Yun Shu, 2006, Artificial receptors in serologic tests for the early diagnosis of dengue virus infection, Clinical Chemistry, 52, 1486-1491.

46.

Dar-Fu Tai*, Chung-Yin Lin, Tzong-Zeng Wu, Li-Kuan Chen, 2005,

Recognition of dengue virus protein using epitope-mediated

molecularly imprinted film, Analytical Chemistry, 77, 5140-5143.

47.

Chung-Yin Lin, Dar-Fu Tai*, Tzong-Zeng Wu, 2003, Discrimination of

peptides using a molecularly imprinted piezoelectric biosensor,

Chemistry-A European Journal, 9, 5107-5110.

研討會論文

1.

Chung-Yin Lin and Dar-Fu Tai, Paper-based molecularly imprinted film designs for sensing human serum albumin, 15^th International Colloids Conference, Sitges, Spain, 2026.

2.

Chung-Yin Lin, Yi-Ting Hwang, and Kuen-Yu Wu, An Innovative System Modeling for Health Risk Assessment on Dioxin Emission, 2024 Annual Meeting – Society for Risk Analysis, Austin, Texas, 2024.

3.

Chung-Yin Lin, Shen-Hung Tsai, and Dar-Fu Tai, Detection of heart natriuretic peptide using a novel amphiphilic monomer produced molecularly imprinted polymers, 10^th International Conference on Molecular Electronics & Bioelectronics, Nara, Japan, 2019.

4.

Chung-Yin Lin, Pin-Yuan Chen, and Kuo-Chen Wei, Strategies for improving the intratumoral distribution of liposomal temozolomide in brain therapy, 2^nd International Conference and Exhibition on Nanomedicine and Drug Delivery, Tokyo, Japan, 2018.

專利

1.

戴達夫; 林中英; 吳宗正「披覆分子印刷膜於晶片上來辨識生物分子」。中華民國專利證號 No. 092107427。

2.

戴達夫; 林中英; 吳宗正; 陳立光; 黃智雄「一種偵測登革熱病毒的新方法」。中華民國專利證號No. 092133959。

3.

Dar-Fu Tai, Chung-Yin Lin, Tzong-Zeng Wu, Discrimination of peptides using a molecularly imprinted biosensor. US patent No. 10/690.600.

4.

Dar-Fu Tai, Chung-Yin Lin, Tzong-Zeng Wu, Method for selective detection of peptides using molecularly imprinted sensors。US patent No. 12/109.352.

5.

劉浩澧, 魏國珍, 陳品元, 許博泓, 朱伯駿, 柴雯燕, 林中英,「以超音波作為傳遞媒介之監控分子通透量的方法」。中華民國專利I562801。

6.

Hao-Li Liu, Kuo-Chen Wei, Pin-Yuan Chen, Po-Hung Hsu, Po-Chun Chu, Wen-Yen Chai, Chung-Yin Lin,「Method for ultrasound-mediated delivery system to monitor molecular penetration」。US patent No. 10076652。