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認證計畫專區

陳郁君老師個人網頁

【個人基本資料】

中文姓名:陳郁君

英文姓名:Yu-Chun Chen

聯絡電話:037-382185

E-mailjoycechen@nuu.edu.tw

1

【主要學歷】

/肆業學校

國別

主修學門系所

學位

國立台灣大學

中華民國

醫學工程學研究所

博士

國立台灣大學

中華民國

醫學工程學研究所

碩逕升博

國立台灣科技大學

中華民國

高分子工程系

學士

【研究專長】

組織工程、醫用高分子材料、醫用水膠、細胞治療、再生醫學

【負責實驗室】

A2-432 組織工程實驗室 Tissue Engineering Lab

【學術著作】

期刊與審查論文

1.

Yung-Hsin Cheng, Shu-Hua Yang, Wen-Yu Su, Yu-Chun Chen, Kai-Chiang Yang, Winston Teng-Kuei Cheng, Shinn-Chih Wu, Feng-Huei Lin*, 2010, “Thermosensitive Chitosan- Gelatin-Glycerol Phosphate Hydrogels as a Cell Carrier for Nucleus Pulposus Regeneration: An In Vitro Study”, Tissue Engineering Part A, 16:695-703

2.

Wen-Yu Su, Yu-Chun Chen, Feng-Huei Lin*, 2010, “Injectable Oxidized Hyaluronic Acid/Adipic Acid Dihydrazide Hydrogel for Nucleus Pulposus Regeneration”, Acta Biomaterialia, 6:3044–55.

3.

Wen-Yu Su, Ko-Hua Chen, Yu-Chun Chen, Yen-Hsien Lee, Ching-Li Tseng, Feng-Huei Lin*, 2011, “An Injectable Oxidated Hyaluronic Acid/Adipic Acid Dihydrazide Hydrogel as a Vitreous Substitute”, Journal of Biomaterials Science, Polymer edition, 22:1777-97

4.

Yu-Chun Chen, Wen-Yu Su, Shu-Hua Yang, Amit Gefen, Feng-Huei Lin*, 2012, “In Situ Forming Hydrogels Composed of Oxidized High Molecular Weight Hyaluronic Acid and Gelatin for Nucleus Pulposus Regeneration”, Acta Biomaterialia, 9:5181-93.

5.

Wen-Yu Su, Yu-Chun Chen, Feng-Huei Lin*, “A New Type of Biphasic Calcium Phosphate Cement as a Gentamicin Carrier for Osteomyelitis”, Evidence-Based Complementary and Alternative Medicine, 2013 (Article ID 801374)

6.

Chih-Hung Chang*, Yuan-Ming Hsu, Yu-Chun Chen, Feng-Huei Lin, Subramaniam Sadhasivam, Siow-Tung Loo, Sivasubramanian Savitha, 2014, “Anti-Inflammatory effects of hydrophilic and lipophilic statins with hyaluronic acid against LPS-induced inflammation in porcine articular chondrocytes”, Journal of Orthopaedic Research, 32(4): 557-65

7.

Karl Wu#, Yu-Chun Chen#, Yuan-Ming Hsu, Chih-Hung Chang*. 2016, March. Enhancing Drug Release from Antibiotic-loaded Bone Cement Using Porogens. Journal of the American Academy of Orthopaedic Surgeons, 24(3): 188–195. (#These authors contributed equally to this work.)

8.

M.H. Hu, K.C. Yang , Y.H. Sun, Y.C. Chen, S.H. Yang*, and F.H. Lin. 2017, Nov. In situ forming oxidised hyaluronic acid/adipic acid dihydrazide hydrogel for prevention of epidural fibrosis after laminectomy. Eurp Cell Mater, 13(34):307-320

9.

Chia-Chun Chen, Chu-Yun Hsiao, Yao-Horng Wang, Yu-Chun Chen, Chih-Hung Chang*, Hsu-Wei Fang*. 2017, Sep. A comparison of distinct bone marrow-derived cells on cartilage tissue engineering. Journal of the Taiwan Institute of Chemical Engineers, 78:32-38

10.

Yeong-Jang Chen, Jwo-luen Pao, Chiang Sang Chen, Yu-Chun Chen, Chun-Chien Chang, Fang-Ming Hung, and Chih-Hung Chang*. 2017. Jan. Evaluation of New Biphasic Calcium Phosphate Bone Substitute: Rabbit Femur Defect Model and Preliminary Clinical Results. Journal of Medical and Biological Engineering, 37(1): 85–93.

11.

Yu-Chun Chen, Yuan-Ming Hsu, Kinn Poay Tan, Chih-Hung Chang*. 2018. Oct. Intraarticular injection for rabbit knee Osteoarthritis: Effectiveness among hyaluronic acid, platelet-rich plasma, and mesenchymal stem cells. Journal of the Taiwan Institute of Chemical Engineers, 91:138–145.

12.

Yu-Chun Chen, Yu-Wei Chang, Kinn Poay Tan, Yi-Shan Shen, Yao-Horng Wang, Chih-Hung Chang*. 2018, Nov. Can mesenchymal stem cells and their conditioned medium assist inflammatory chondrocytes recovery? PLOS ONE, 13(11):e0205563.

13.

Yu-Chun Chen, Chih-Hung Chang*. 2020 July. Clinical Application of Mesenchymal Stem Cells for Cartilage Regeneration. Journal Plastic and Aesthetic Research, 7:49.

14.

賴建成、陳郁君、雷涵媮、張至宏*。2020 Nov. 退化性膝關節炎再生醫學治療及醫病共享決策之應用Applications of Shared Decision Making for Regenerative Treatment of Knee Osteoarthritis. Formosan Journal of Medicine, 24:6, 659-664.

15.

Karl Wu, Yu-Chun Chen, Shang M Lin, Chih-Hung Chang*. 2021 May. In vitro and in vivo effectiveness of a novel injectable calcitonin-loaded collagen/ceramic bone substitute. Journal of Biomaterials Applications. 35(10):1355-1365. doi: 10.1177/0885328221989984. Epub 2021 Jan 31.

16.

Yu-Chun Chen, Hwa-Chang Liu, Feng-Huei Lin and Chih-Hung Chang*. 2021 March. Development of Engineered Cartilage Product from Bone Marrow Mesenchymal Stem Cells: An Example in Taiwan. Journal of Musculoskeletal Research VOL. 24, NO. 01

17.

Hung-Hsuan Chen#, Yu-Chun Chen#, San-Ni Yu, Wan-Ling Lai, Yi-Shan Shen, Pei-Chun Shen, Siao-Han Lin, Chih-Hung Chang*, Shing-Mou Lee*. 2022 Jan. Infrapatellar fat pad–derived mesenchymal stromal cell product for treatment of knee osteoarthritis: a first-in-human study with evaluation of the potency marker. Cytotherapy. 24(1):72-85. doi: 10.1016/j.jcyt.2021.08.006. Epub 2021 Oct 22
# contributed equally

18.

Yu-Chun Chen, Hsiu-Jung Liao, Yuan-Ming Hsu, Yi-Shan Shen, and Chih-Hung Chang*. 2022 Apr. 05. Delivery of Mesenchymal Stem Cell in Dialdehyde Methylcellulose-Succinyl-Chitosan Hydrogel Promotes Chondrogenesis in a Porcine Model. Polymers 2022, 14(7), 1474; https://doi.org/10.3390/polym14071474

19.

Chen, Hung-Hsuan#; Chen, Yu-Chun#; Yu, San-Ni; Lai, Wan-Ling; Shen, Yi-Shan; Shen, Pei-Chun; Lin, Siao-Han; Chang, Chih-Hung; Lee, Shing-Mou*# contributed equally.2022 Jan. Infrapatellar fat pad-derived mesenchymal stromal cell product for treatment of knee osteoarthritis: a first-in-human study with evaluation of the potency marker. Cytotherapy 2022, 24(1),72-85.

研討會論文

1.

Yu-Chun Chen, Feng-Huei Lin*, 2007, “In Vitro Biocompatible Evalua-tion of Nucleus Pulposus Cells Cultured in Hyaluronan/Alginate Beads” 4th European Symposium on Biopolymers (ESBP), Oral presentation.

2.

Yu-Chun Chen, Wen-Yu Su, Feng-Huei Lin*, 2009, “Injectable Hy-aluronic Acid / Adipic Acid Dihydrazide for Nucleus Pulposus Regeneration”, Annual Meeting of Formosa Association of Regenerative Medicine Oral presentation

3.

Yu-Chun Chen, Wen-Yu Su, Feng-Huei Lin*, 2010, “In Situ Forming Hyaluronic Acid Hydrogel for Nucleus Pulposus Regeneration : Rheological Properties and Gene Expression”, International Symposium of Materials on Regenerative Medicine (ISOMRM), Oral presentation

4.

Yu-Chun Chen, Wen-Yu Su, Feng-Huei Lin*, “Rheological Characterization of Injectable Hyaluronic Acid Hydrogel for Nucleus Pulposus Regeneration”, NHRI Research Day, Mar., 2010, Zhunan, Taiwan, Poster Presentation (Excellent Poster Award)

5.

Yu-Chun Chen, Wen-Yu Su, Feng-Huei Lin*, 2011, “In Situ Forming Hyaluronic Acid Hydrogel for Nucleus Pulposus Regeneration: Rhe-ological Properties and Gene Expression”, Tissue Engineering International & Regenerative Medicine Society (TERMIS), Oral presentation

6.

Wen-Yu Su, Yu-Chun Chen, Feng-Huei Lin*, “An Injectable Oxidated Hyaluronic Acid/Adipic Acid Dihydrazide Hydrogel as a Vitreous Substitute”, NHRI Research Day, Mar., 2011, Zhunan, Taiwan, Poster presentation

7.

Yu-Chun Chen, Wen-Yu Su, Feng-Huei Lin*, “Injectable Hyaluronic Acid-Gelatin Hydrogel for Nucleus Pulposus Regeneration: Viscoelastic Properties, Cell Behavior, and Gene Expression Analysis”, NHRI Research Day, Mar., 2012, Zhunan, Taiwan, Poster presentation

8.

Yu-Chun Chen, Wen-Yu Su, Feng-Huei Lin*, “In Situ Forming Hyaluronic Acid-based Hydrogel for Nucleus Pulposus Regeneration: An Experimental Study Using an Animal Model”, NHRI Research Day, Mar., 2013, Zhunan, Taiwan, Oral Presentation (Elected Paper Award)

9.

Yu-Chun Chen, Kinn Poay Tan, Chih-Hung Chang*, 2014, “Bone Marrow Mesenchymal Stem Cells Reduced LPS- Induced Inflammatory Response in Chondrocytes”, World Congress on Preventive and Regenerative Medicine (WCPRM), Oral presentation.

10.

Yu-Chun Chen, Yuan-Ming Hsu, Ruo-Yu Chen, Chih-Hung Chang*, 2014, “Acellular Cartilage Matrix for Cartilage Tissue Engineering: Preparation, Characterization, and Biocompatibility Evaluation”, World Congress on Preventive and Regenerative Medicine (WCPRM), Oral presentation.

11.

Yu-Chun Chen, Yuan-Ming Hsu, Kinn Poay Tan, Chih-Hung Chang*, 2015, “Comparison of Platelet-rich Plasma or Hyaluronic Acid with/without Bone Marrow Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis in a Rabbit Model”, Annual Meeting of Formosa Association of Regenerative Medicine, Oral presentation.

12.

u-Chun Chen, Ruo-Yu Chen, Yuan-Ming Hsu and Chih-Hung Chang*, 2016, “Acellular Cartilage Matrix Combined with Chtosan Cellulose Hydrogel for Cartilage Regeneration: Cell-compatibility and Gene Expression Analysis”, 2016 Tissue Engineering and Regenerative Medicine International Society- Asia Pacific Meeting, Oral presentation.

13.

Yu-Chun Chen, Yi-Shan Shen, Feng- Hui Lin, Chih-Hung Chang*, 2016, “In Situ Forming Thermosensitive Hydrogel Combined with ACM for One-stage Cartilage Defect Treatment”, Annual Symposium on Biomedical Engineering and Technology Engineering and Technology, Poster presentation.

14.

Yu-Chun Chen, Ruo-Yu Chen, Yi-Shan Shen,Yuan-Ming Hsu and Chih-Hung Chang*, 2017, “Acellular Cartilage Matrixc Combined with Chitosan Cellulose Hydrogel for Cartilage Regeneration: Cellcompatibility and Gene Expression Analysis”, International Conference of Development Biology, Stem Cell and Regenerative Medicine, Poster presentation.

15.

Yu-Chun Chen, Wen-Yu Su, Yi-Shan Shen, Feng- Hui Lin and Chih-Hung Chang*, 2018, “Hyaluronic Acid-based Thermosensitive Hydrogel Combined with Acellular Cartilage Matrix for Cartilage Defect Treatment” IUPESM 2018 - World Congress on Medical Physics & Biomedical, Oral presentation

16.

Yu-Chun Chen, Hung-Hsuan Chen, Ni-En Jiang, Yi-Shan Shen, Hsiu-Jung Liao, Shing-Mou Lee, Chih-Hung Chang. 2021. Anti-inflammation effect of infrapatellar fat pad mesenchymal stem cell for osteoarthritis treatment. Tissue Engineering and Regenerative Medicine International Society (TERMIS) World Congress, Maastricht, Netherlands. Online Meeting.

17.

Ching-Wen Chang, Kuo-Teng Hsu, Yu-Chun Chen*. 2022. Development of Quercetin contained Hyaluronic Acid Hydrogel as a Vitreous Substitute. Annual Meeting of Biomaterials and Controlled Releases Society in Taiwan. Hsinchu, Taiwan. Poster presentation.

18.

Yun-Qing Sun, Yan-Ping Song, Yu-Chun Chen*. 2022. Anti-Inflammation Ability Evaluation of Different Cultivation Microenvironment Mesenchymal Stem Cell Derived Exosome. Annual Meeting of Biomaterials and Controlled Releases Society in Taiwan. Hsinchu, Taiwan. Poster presentation

19.

Yu-Ping Chen, Chih-Hung Chang, Feng-Huei Lin, Yu-Chun Chen*. 2022. The Study of Extracellular Vesicles Derived from Micromass Cultivated MSC for Cartilage Matrix Synthesis Promotion. MRS-Taiwan Annual Meeitng, Miaoli, Taiwan. Poster presentation.

發明專利

1.

Feng-Huei Lin, Wen-Yu Su, Yu-Chun Chen, Ko-Hua Chen. “Cross-linked oxidized hyaluronic acid for use as a vitreous substitute.” United States Patent US8,197,849 B2. 2012/06~2030/08

2.

林峯輝、蘇文郁、陳郁君、陳克華,交聯氧化玻尿酸作為眼球玻璃體之替代物,中華民國TWI389713,專利期間2013/03~2030/10

3.

林峰辉、苏文郁、陈克华、陈郁君交联氧化透明质酸作为眼球玻璃体之替代物,中華人民共和國CN 102762647 A,專利期間2014/12~2032/10

4.

Feng-Huei Lin, Wen-Yu Su, Yu-Chun Chen, Ko-Hua Chen. “Cross-linked oxidized hyaluronic acid for use as a vitreous substitute.” Australian Patent AU2011215775B2. 2012/04~2031/02

5.

Feng-Huei Lin, Wen-Yu Su, Yu-Chun Chen, Ko-Hua Chen. “Cross-linked oxidized hyaluronic acid for use as a vitreous substitute.” Patent Cooperation Treaty (PCT) WO2011100469A1. 2011/08~2031/02

6.

Feng-Huei Lin, Wen-Yu Su, Yu-Chun Chen, Ko-Hua Chen. “Cross-linked oxidized hyaluronic acid for use as a vitreous substitute.” Spain Patent ES2535115T3. 2015/05~2031/02

7.

Feng-Huei Lin, Wen-Yu Su, Yu-Chun Chen, Ko-Hua Chen. “Cross-linked oxidized hyaluronic acid for use as a vitreous substitute.” European Patent EP2534200B1. 2015/04~2031/02

8.

Feng-Huei Lin, Wen-Yu Su, Yu-Chun Chen, Ko-Hua Chen. “Cross-linked oxidized hyaluronic acid for use as a vitreous substitute.” Canada Patent CA2786911C. 2015/10~2031/02

9.

Yu-Chun Chen, Wen-Yu Su, Yen-Hsien Lee, Ko-Hua Chen, Feng-Huei Lin. “Gamma-polyglutamic acid-based ocular irrigating solutions” Patent Cooperation Treaty (PCT) WO2011127221A1. 2011/10~2031/04

10.

Yu-Chun Chen, Wen-Yu Su, Yen-Hsien Lee, Ko-Hua Chen, Feng-Huei Lin. “Gamma-polyglutamic acid-based ocular irrigating solutions” European Patent EP2555780B1. 2016/02~2031/04

11.

陈郁君苏文郁李彦贤陈克华林峰辉γ-聚麸胺酸类眼科手术冲洗液,中華人民共和國CN102939092B. 2015/10~2031/04

12.

Yu-Chun Chen, Wen-Yu Su, Yen-Hsien Lee, Ko-Hua Chen, Feng-Huei Lin. “Gamma-polyglutamic acid-based ocular irrigating solutions” Australian Patent AU2011237671B2. 2014/04~2031/04

13.

Yu-Chun Chen, Wen-Yu Su, Yen-Hsien Lee, Ko-Hua Chen, Feng-Huei Lin. “Gamma-polyglutamic acid-based ocular irrigating solutions” Canada Patent CA2794563C. 2014/11~2031/04

14.

林峯輝、陳郁君、蘇文郁、李彥賢、陳克華γ-聚麩胺酸類眼科手術沖洗液中華民國TWI482639B. 2015/05~2031/04

15.

Yu-Chun Chen, Wen-Yu Su, Yen-Hsien Lee, Ko-Hua Chen, Feng-Huei Lin. “Gamma-polyglutamic acid-based ocular irrigating solutions” United States Patent US9457000B2. 2016/10~2031/06

 

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